Recent Advances in Head and Neck Cancer—Larynx Preservation and Cancer Chemoprevention: The Seventeenth Annual Richard and Hinda Rosenthal Foundation Award Lecture1
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چکیده
Head and neck cancer is a major public health problem. In the United States alone, approximately 43,000 new cases of head and neck cancer will be diagnosed and 11,000 persons will die of the disease in 1993 (1, 2). Worldwide, over 500,000 new cases of this cancer occur yearly, and the incidence is rising. Furthermore, despite intensive efforts in primary prevention, screening, and therapy, longterm survival rates have not improved substantially since the 1960s. Standard treatment for head and neck cancers consists of surgery, radiotherapy, or both, and is met with mixed results. Standard treat ment is frequently initially successful in early stage disease, but even in early stage disease, initial success is tempered by the potential for long-term development of deadly SPT.3 Against advanced disease,
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